Event Date
Dr. Danny JJ Wang is Professor of Neurology and Radiology, Director of Imaging Technology Innovation at the Stevens Neuroimaging and Informatics institute, University of Southern California (USC), as well as head of the Laboratory of Functional MRI technology (LOFT). During the past 25+ years, his research has been focused on the technical development and clinical translations of novel medical imaging technologies, including perfusion and functional MRI with clinical applications related to cerebrovascular disorders, dementia and neurodevelopment, as well as development at ultrahigh field. He has been supporting the scientific community by disseminating arterial spin labeling (ASL) MRI sequences to >300 imaging research centers around the world. He is Fellow of ISMRM and AIMBE. He initiated the 7T Translational Alliance of North America (7TANA.org) to facilitate the clinical translation of ultrahigh field MRI.
Cerebral small vessel disease (cSVD) is the most common vascular cause of dementia. However, cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing in vivo imaging technologies. During the past decade, our group at the Laboratory of FMRI Technology (LOFT) has spearheaded the development of a suite of MRI techniques at 3 and 7T for in vivo imaging and quantification of the morphology and function of cerebral small vessels, including high-resolution black blood MRI, arterial spin labeled (ASL) perfusion and diffusion-weighted ASL for mapping BBB water exchange. In this talk, I will summarize recent technical development and applications of these techniques in aging, cerebral SVD, cognitive decline and dementia. I will also present laminar perfusion and metabolic imaging at 7T for understanding neural circuit function across cortical layers.