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MR Fingerprinting (MRF) is a quantitative imaging technique capable of generating multiple tissue property maps simultaneously from a single MR scan. With demonstrated clinical feasibility, MRF has been successfully designed for various body regions and diseases. In multisite studies spanning multiple vendors, MRF has shown high reproducibility for tissue property mapping, overcoming scanner variations and other confounding factors. This makes MRF a powerful imaging tool for ensuring high quality control of the MRI source data, which is critical for subsequent analysis and informed clinical decision-making. By integrating the precision and sensitivity of MRF with cutting-edge image analysis techniques, we developed a comprehensive quantitative imaging framework, enabling improved diagnosis for epilepsy and brain tumors and early prediction of treatment responses.